Sean Bean marries for fourth time & other: 2008

Thursday 4 September 2008

Algeta Reports Positive Headline Phase II Data On Pain Palliation With Alpharadin

�Algeta ASA (OSE: ALGETA), the Norwegian cancer therapeutics company, announced that the primary objective of its BC1-03 Phase II bother
palliation survey was met. The study showed that even single doses of
Alpharadin in patients with painful bone metastases could produce
increasing clinical benefit with increasing dose. Pain palliation is an
important quality of life benefit in metastatic cancer patients. The tribulation
also confirmed Alpharadin's benign side-effect visibility and, importantly for
a drug in this clinical setting, no significant os marrow toxicity was
observed.

In manpower with HRPC life anticipation can be as short as 18 months, and it
is estimated that 100,000 men in the EU and USA die from the disease each
year. In 85% of these men the tumor will have spread into the bones. These
metastases ar a pregnant problem as they bathroom cause intractable and
debilitating pain as well as contributing to a farther reduction in life
expectancy.

The BC1-03 study was a double blind randomised pain control study
comparing the palliative personal effects of four-spot different single dose levels of
Alpharadin in patients with boney metastatic HRPC. The do drugs was given by
i.v. shot mainly on an outpatient basis. The palliative efficaciousness of
Alpharadin was deliberate using an assessment of bone pain as comfortably as the
patient's consumption of analgesia. The primary study objective was to
investigate whether there was a dose-response relationship with respect to
pain palliation in this patient group. The study has shown the good
palliative effect of a single dosage of Alpharadin and that there is a net
dose-response effect, with higher doses providing better pain in the ass relief.

The study likewise showed a dose-dependent simplification in os alkaline
phosphatase (ALP) ranging from no effect in the lowest dose mathematical group to a
marked reduction in the higher dot groups. ALP is a severity marker of
gaunt metastatic disease and of prognostic importance.

The study has also further confirmed the safe of Alpharadin and shown
its benign side-effect profile. In fact, the higher the elvis of Alpharadin
that patients received, the fewer inauspicious events were experienced. This
reproduces the safety profile of the earlier BC1-02 Phase II study where
the Alpharadin group experienced fewer inauspicious effects than the placebo
comparator group. Importantly for a do drugs in this clinical setting no
significant bone marrow toxicity was observed in patients receiving
Alpharadin.

The full results of the BC1-03 study will be submitted for publication
in a peer-reviewed journal.

The principal research worker of the study Professor Sten Nilsson at the
Karolinska Hospital in Stockholm said: "These results display the
good impact of Alpharadin in terms of pain palliation are important,
as improved quality of life, aboard increased survival, are the two key fruit
goals of anti-cancer therapy of patients with pinched metastases."

Commenting on today's further positive news with Alpharadin, Algeta's
President and CEO, Dr. Thomas Ramdahl, said: "These results build on the
positive Phase II clinical data package that we have already assembled with
Alpharadin, the highlight of which was the substantial survival benefits
that we have already reported in patients with HRPC.

Based on our clinical trials to-date I am identical confident that
Alpharadin has the potency to become an crucial new therapy for
patients with prostate cancer. This view has been reinforced by the
enthusiastic and positive response we have received from key judgment
leaders around the humans to our unique coming to treating HRPC."

Algeta has lately started enrolling patients for the polar Phase
III ALSYMPCA (ALpharadin in SYMptomatic Prostate CAncer) study. This
international written report will valuate Algeta's targeted therapeutic Alpharadin
in advanced, hormone-refractory prostate gland cancer (HRPC) that has
metastasized to the skeleton. Approximately 750 patients ar expected to be
enrolled at more than cxxv medical centers in Europe, Asia, South America
and Canada. The Coordinating Investigator for the study is Dr. Christopher
Parker, a leading clinical oncologist and specialist in prostate cancer the Crab,
based at the Institute of Cancer Research and the Royal Marsden Hospital in
the UK.

About Algeta

Algeta ASA is a Norwegian genus Cancer therapeutics company built on
world-leading, proprietary technology. Algeta is developing new, targeted
cancer therapeutics that harness the alone characteristics of alpha
subatomic particle emitters and are virile, well-tolerated and convenient to use.

Algeta's lead product candidate, Alpharadin, has commenced an
international phase III clinical trial in hormone-refractory prostate
cancer (ALSYMPCA) based on positive phase II results. Alpharadin is a novel
bone-seeking therapeutic based on the alpha particle emitter radium-223 and
may target wasted metastases from multiple genus Cancer types, as well as
primary ivory cancers.

Algeta is besides developing other technologies for delivering alpha
emitters. These include microparticles, liposomes, and methods to enhance
the potency of therapeutic antibodies and other tumor-targeting molecules
by linking them to the alpha particle

Monday 25 August 2008

Clinical News From Annals Of Internal Medicine

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Thursday 7 August 2008

Meg Ryan - Crowe Romance Rocked Ryans World

MEG RYAN was so upset by the way America turned on her during her 2000 romance with PROOF OF LIFE co-star RUSSELL CROWE she needed to take a break from Hollywood to recover.

The actress had long been considered America's lulu until the break-up of her

Friday 27 June 2008

DJ Niekos

Artist: DJ Niekos

   Genre(s):
Techno

Discography:

Promo

Year: 2002
Tracks: 1

Sunday 22 June 2008

Shins set to release album on Mercer's label

Indie band's first three albums were on Sub Pop

NEW YORK -- The Shins are likely to self-release their fourth studio album through frontman James Mercer's Aural Apothecary label. The beloved indie rock group's first three albums were released by Sub Pop.
"The deal will be more of a (pressing and distribution) deal than a traditional record deal," Shins manager Ian Montone said. "That partner could very well remain Sub Pop, who have done a remarkable job with the band and have a great staff of people who really love music. It could be a digital partner with respect to other rights. All of this is being determined. The first goal is to make the record and see where that takes us."
The Shins are seeking a deal that would allow them to own their masters, "and, in addition to the marketing tools we have at our own disposal, team up with a label partner that will assist with additional marketing, radio, and various costs," Montone reported.
For a band like the Shins, who have sold 1.58 million albums in the United States since 2001, according to Nielsen SoundScan, such a deal makes sense because "it allows them to have the best of all possible worlds -- control and ownership, as well as the ability to still partner with a label and be able to take advantage of that traditional infrastructure," according to Montone.
The band's most recent album, 2007's "Wincing the Night Away," debuted at a career-best No. 2 on the Billboard 200 and has sold more than 538,000 copies.

Sunday 15 June 2008

Hbo - Former Critic Frank Rich To Help Develop Shows For Hbo

New York Times
Op-Ed columnist Frank Rich is becoming a "creative consultant" to HBO to participate
in the development of new programs. Rich has been a film and TV critic for Time
and a theater critic for the New York Times from 1980-1994. Rich told the
Times today (Thursday) that his role at HBO will be "to bring ideas, to vet
ideas, everything from comedies to documentaries to docudramas."

22/05/2008

See Also

Monday 2 June 2008

Ali Wilson And DMF

Artist: Ali Wilson And DMF

   Genre(s):
Trance

Discography:

Emanation

Year: 2007
Tracks: 1

Jennifer Aniston is a “clingy” girlfriend

Tuesday 27 May 2008

Vanessa Hudgens - Disney Star Hudgens Working On Adult Album

Singer/actress VANESSA HUDGENS is desperate to follow in the footsteps of HIGH SCHOOL MUSICAL co-stars ZAC EFRON and ASHLEY TISDALE with her upcoming album IDENTIFIED.

Hudgens, 19, who plays Efron's love-interest in real life and on-screen, hopes the solo project will catapult her career into a more adult direction - although she admits the album isn't a full departure from her Disney roots.

She says, "It's definitely more grown-up. But not to the point where I'm singing, 'I'm so hot! I'm so hot! Boys want me. I'm so hot!'"

Hudgens came under fire when nude photographs of the star were leaked online last year (Aug07).

See Also

Sunday 18 May 2008

Tabloid claims about Newman's health denied

Reports that film legend Paul Paul Newman has undergone a arcanum surgery to save up him from cancer ar unfounded, according to the actor's representative.
Rabbit warren Cowan revealed that he rung with Cardinal Newman around the claims by tabloid magazine The Querier.
Newman said: "I'm organism treated for athlete's foundation and pilus red ink... mayhap the doctors know something that I don't!"
Whilst Newman has retired from playing he distillery spends considerable clock time working for his various charities.
The sensation, wHO has appeared in numerous photographic film classics including 'Butch Cassidy and the Sundance Kid' and 'Cool Hand Luke', founded the Barretstown charity in Kildare in 1994.
To day of the month o'er 10,000 children with cancer and other serious illnesses take benefited from the charity.

Thursday 8 May 2008

New romance for Girls Aloud singer?

Girls Out loud star Nadine Coyle has reportedly begun a fresh romance with dancer Jamie Karitzsis.
According to The Mirror, the singer, world Health Organization late rip from 'Desperate Housewives' star Jesse Metcalfe, is now geological dating the dancer, world Health Organization starred in the reality express 'Dirty Terpsichore: The Time of Your Life'.
A source told the paper: "Nadine has known Jamie for about a twelvemonth now."
"They dated for a duet of months death year during unity of her splits with Jesse only work commitments place paid to their romance language."
The source also said: "They let stayed in touch and met up late, although they hadn't seen from each one other for ages. Nadine genuinely liked him and they've been on a few dates all over the conclusion match of weeks."
"She wants to keeps things out of the world eye and take it slow. She and Jamie give birth been friends, which is a good thing. He's been there for her."

Monday 5 May 2008

Universal Music Group (UMG) Closes Acquisition of Univision Music Group

New Merged Company to be Known as Universal Medicine Latin Amusement & LED
by The Nazarene Lopez

New York and Miami, Whitethorn 5 -- Universal joint Music Mathematical group (UMG),
the world's leading music company, today announced that it has completed
its acquisition of Univision Euphony Mathematical group pursuit the recent epoch clearance of
the deal in the U.S. by the Federal Swap Military commission. The acquisition
results in UMG becoming the largest Latin music troupe in North America.

The combined company, which will control under the Universal Music
Latin Entertainment standard, volition include Linguistic universal Music Latino, Panga,
the newly acquired labels from the Univision purchase -- Fonovisa and Disa,
Universal proposition Music United Mexican States & Exchange America, Latin publication in the US and
Mexico, including the fresh acquired Edimonsa, Defense Information Systems Agency and the Fonovisa
catalogs, and GTS Global Talent Services, a direction service division. As
portion of this acquisition, the Univision constitute will be phased out. Universal proposition
Music Latin Entertainment will be a partition of Universal Music Latin
U.S., and will be lED by Saviour Lopez (currently Chairperson & Chief operating officer of Latin
America and Iberian Peninsula). Mr. Lopez will continue to be based in
Miami, FL and reputation to Zach Horowitz (President & Coo, Universal proposition
Music Mathematical group) for Universal proposition Medicine Latin Amusement.

"Saviour has presided over a period of remarkable increment for Universal proposition
Music Latin America," stated Mr. Horowitz. "His vision and passion for
Latin music, entrepreneurial instincts and ability to think 'out of the
box,' combined with that rare talent of being able to correspondence both creative
and business sector concerns, make up him the ideal person to lede the fresh merged
company."

"I am rightfully grateful to Zach for this exciting opportunity," commented
Mr. Lopez. "It is a privilege to continue working so intimately with him and
the stallion Latin music team as we build this new company, finish with
such a rich history and one of the almost moral force groups of artists and
executives in the business."

In addition, it was besides announced today that Jose Behar, President of the United States of
Univision Medicine Radical, has deceased the company.

"I'd too like to take this opportunity to recognise all of the
contributions that Jose has made to Univision over the years," added Mr.
Lopez. "We sure as shooting wish him the very best in whole of his future
endeavors."

Universal Music Latin Amusement possesses a roll of chart-topping
artists as well as a vast catalogue that comprises just about of the almost important
Latin recordings in history. Its artists include Juanes, Juan Gabriel,
Paulina Rubio, Preceptor Omar, La Secta, Winsin & Yandel, Alicia Villarreal,
Pedro Fernandez, La Factoria, Mach & Daddy, Enrique Julio Iglesias, Belanova,
Luis Fonsi, Coffee bar Tacuba, Marco Antonio Solis, Los Tigres del Norte, Los
Temerarios, Horoscopos de Durango, K-paz de la Sierra, Grupo Montes de
Victoria de Durango, Alacranes Musicales, Conjunto Primavera, Banda El Recodo, Jenni
Rivera, Gloria Trevi, Graciela Beltran, Xtreme, Olga Tanon, Marshal Tito Nieves,
Bajofondo Tango Golf club, and Hedera helix Queen, among many others.

About Universal Music Group

Universal Music Grouping is the world's largest music company with completely
owned record operations or licensees in 77 countries. Its businesses likewise
include Universal Music Publishing Radical, the industry's leading global
music publication operations. Its labels include Decca, Deutsche Grammophon,
Interscope Geffen A&M Records, Island Def Jam Music Group, Lost Highway
Records, Machete Music, MCA Capital of Tennessee, Hydrargyrum Capital of Tennessee, Mercury Records,
Philips, Polydor Records, Linguistic universal Music Latin US, Universal joint Detroit
Democracy Group, Universal Due south Records and Verve Music Mathematical group, as well as a
concourse of record labels owned or distributed by its record troupe
subsidiaries around the reality. The Universal Music Group owns the to the highest degree
extensive catalogue of music in the industry, which is marketed through two
distinct divisions, Linguistic universal Music Enterprises (in the U.S.) and Universal
Strategic Marketing (exterior the U.S.). Universal Music Group as well includes
eLabs, a new media and technologies section, Bluster, its marketing
company, and Twenty-First Artists, its wax service management part.

Universal proposition Music Group is a unit of Vivendi, a global media and
communications society.

Press contact: Peter LoFrumento or Mare Ho-Burge, 212 331 2569

Winehouse's mother says she's recovering

Amy Winehouse's mother Janis has spoken most her daughter's Grammy achiever, locution that she believes the isaac Bashevis Singer is on "the road to recovery".
Winehouse picked up five Grammy awards just could not attend the ceremonial in Los Angeles because of visa problems. She performed at the event via satellite from British capital.
Speaking on 'GMTV', Janis Winehouse said: "Easily, as you saw, she looks good and it's a case of she's on the road, and that's what it's about, she's on the route to recovery."
"I believe it would have been also often for her because completely of the travel and flying there, I mean seeing what the Grammys was like... we could realise it survive from there and I mentation if Amy were there, she'd be lost in it, she'd be a little girlfriend lost in it."
Speech production about her daughter's Grammys public presentation, she said: "Well, it's Amy orgasm back, she's in spades on the way plunk for."
The star's mother also spoke around her fears for her daughter's health before she entered rehab, locution: "She was sorting of with it merely non with it, and that's the thing where I think fortunately, thank good in our family, she's got a solid family and we're whole on that point for her."

Dj godfather

Crow says Aniston ended marriage to Pitt

Instrumentalist Sheryl Vaporing has contradicted the widely held notion that Brad First Earl of Chatham left wife Jennifer Aniston after meeting Angelina Jolie.
Vaporing, world Health Organization became close with the former 'Friends' asterisk later on her break up with cyclist Lancet Louis Armstrong, insists that Aniston was the single wHO ended the relationship in 2005.
Speech production to Contactmusic Crow said: "For both of us, the perceived estimate is that, in our big relationships, we both got dumped. Believe me, this is not true".
She added: "No one ever knows what goes on in relationships. Unluckily, for about masses like Jennifer and me, so much is written about things that you don't say and so many emotions are attributed to you that you haven't had," she added.
Ever so since George Pitt and Jolie became shut on the set 'Mr and Mrs. Smith', it had been believed that the thespian left his married woman for Jolie.
Notwithstanding a number of Aniston's pals have presumption credenza to Crow's claims and one champion told the Subject Inquirer: "Once Jen saw the authorship on the wall, she dumped Brad. She took a common cold, hard look at her marriage and realised it was irretrievably broken".
They added: "She and Brad had immensely different personal agendas and feelings about love life, calling and having a kinsfolk."

Eric Clapton invited to play in North Korea

Eric Clapton has been invited to perform in the secretive commonwealth of Magnetic north Han-Gook, it emerged yesterday.
Stone and bulge out take been banned in the world's to the highest degree isolated state because of fears over western influences.
But the legendary English singer and guitar player has been asked to perform in the capital Capital of North Korea next year, according to the Financial Times.
Diplomats trust the feeler shows that the communist state wants to construct cultural bridges with the West, even though discussions all over its nuclear programmes have stalled.
Clapton, whose hits include 'Cocaine', 'Layla', and 'Tears in Heaven', has agreed in principle to the mind, according to the newsprint.
The request comes as the Newly House of York Symphony performs in Pyongyang followers a request from the country's officials.
The Philharmonic is the low gear major US cultural grouping to do in Union Korean Peninsula, which US President George Chaparral classed as section of the "axis of evilness".
The North Korean State Symphonic music Orchestra plans to do in Capital of the United Kingdom this summer as piece of the orchestra's biggest e'er tour, and Clapton has been invited to the area in return.
A North Korean official told the Financial Multiplication: "We want our music to be understood by the western sandwich world and we want our people to understand western sandwich music."
62-year-old Clapton, nicknamed Slowhand, has been ranked one-quarter in Rolling Stone Magazine's heel of the hundred Greatest Guitarists of Completely Time.
He was inducted into the Rock and roll and Undulate Manse of Renown an unprecedented triplet times as a band member in The Yardbirds and Cream and as a soloist.